NEURAPRO: A multi-centre RCT of omega-3 polyunsaturated fatty acids versus placebo in young people at ultra-high risk of psychotic disorders - Medium-term follow-up and clinical course

B Nelson; GP Amminger; HP Yuen; C Markulev; S Lavoie; MR Schäfer; JA Hartmann; N Mossaheb; M Schlögelhofer; S Smesny; IB Hickie; G Berger; EYH Chen; L De Haan; DH Nieman; M Nordentoft; A Riecher-Rössler; S Verma; A Thompson; AR Yung; PD McGorry

Conference Proceedings

NEURAPRO: A multi-centre RCT of omega-3 polyunsaturated fatty acids versus placebo in young people at ultra-high risk of psychotic disorders - Medium-term follow-up and clinical course

B Nelson, GP Amminger, HP Yuen, C Markulev, S Lavoie, MR Schäfer, JA Hartmann, N Mossaheb, M Schlögelhofer, S Smesny, IB Hickie, G Berger, EYH Chen, L De Haan, DH Nieman, M Nordentoft, A Riecher-Rössler, S Verma, A Thompson, AR Yung Show all

Npj Schizophrenia | NATURE PORTFOLIO | Published : 2018

DOI: 10.1038/s41537-018-0052-x

Abstract

This study reports a medium-term follow-up of a randomised, double-blind, placebo-controlled trial of omega-3 polyunsaturated fatty acids (PUFA) in ultra-high risk for psychosis (UHR) patients. Primary outcomes of interest were transition to psychosis and symptomatic and functional outcome. A secondary aim was to investigate clinical predictors of medium-term outcome. Three hundred four UHR participants were recruited across 10 specialised early psychosis services in Australia, Asia, and Europe. The intervention consisted of 1.4 g/daily of omega-3 PUFA or placebo, plus up to 20 sessions of cognitive-behavioural case management (CBCM), over the 6-month study period, with participants receivin..

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University of Melbourne Researchers

Barnaby Nelson Author

Paul Amminger Author

Hok Yuen Author

Connie Markulev Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by Grant 07TGF-1102 from the Stanley Medical Research Institute, a National Health and Medical Research Council (NHMRC) Australia Program Grant (ID: 566529; P.D.M., I.B.H., A.R.Y., G.P.A.) and a grant from the Colonial Foundation. B.N. was supported by an NHMRC Career Development Fellowship (ID: 1027532) and a University of Melbourne Faculty of MDHS Fellowship. P.D.M. was supported by a Senior Principal Research Fellowship from the NHMRC (ID: 1060996). G.P.A. and A.R.Y. were supported by NHMRC Senior Research Fellowships (ID: 1080963 and 566593).